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A secondary analysis of clinical trial data found that up to 40% of weight lost on semaglutide can be lean mass -- muscle and bone -- rather than fat, particularly in women and older adults

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Gastrointestinal (GI): Nausea and abdominal pain, or mild GI upset

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Employers only pay when predefined outcomes are achieved Guaranteed improvements in A1C, weight loss, and deprescription of GLP-1s and other medications ROI is validated using pharmacy and medical claims data Reported outcomes include a 2.2-point average A1C reduction for members with starting A1C greater than8.0 and a 14-pound average weight loss for members with a BMI greater than 30, based on internal data from Twin Healths commercial populations as of September 2024 Demonstrated reductions in diabetes-related pharmacy spend while maintaining clinical appropriateness Precision medication management Employers can start by using claims and clinical data to identify risk levels and guide GLP-1 eligibility