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While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional medicines with distinct modes of action as independent or complementary therapeutics

Translational superiority of GLP-1R/GCGR dual agonism versus GLP-1R on the body weight benefit was later demonstrated in obese rhesus monkeys (47, 48) and confirmed by other groups (49)

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Lillys Mounjaro (tirzepatide), a GIP/GLP-1 dual agonist, demonstrated cardiovascular protection in landmark head-to-head trial, reinforcing its benefit in patients with type 2 diabetes and heart disease

Heart Fail Rev 30 , 131136 (2025)

Rapid Weight Loss Losing weight too quickly can stress the body and cause temporary fatigue as your metabolism and hormone levels adjust