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mean HbA1c, 7.8%)

Ongoing research continues to evaluate the role of these agents in populations without diabetes, particularly in the context of obesity and primary cardiovascular prevention, suggesting that their therapeutic reach may expand further in the coming years

In Phase 2 trials, retatrutide, a GIP/GLP-1/glucagon based triple agonist, achieved a mean bodyweight reduction of up to 24.2% over 48 weeks

Trial registration UMIN000011118 (date of registration: July 4, 2013)

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Not reviewed by FDA for safety, efficacy, or quality