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A drugs half-life is the time it takes for its blood level to fall by 50 %
However, our approach is a significant advance on these earlier methods, for the following reasons: snap-freezing of samples followed by reaction with IAM-TPP/IAM enables us to trap and stablise all reactive sulfur species simultaneously through their nucleophilic reactions to generate stable products, rather than leaving labile moieties that may be modified during sample workup
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Direct head-to-head Phase 3 comparison data from the TRIUMPH-3 trial is not yet available
Realistic expectations focus on appetite control and metabolic health support, not the dramatic results seen in randomized controlled trials of prescription GLP 1 medications
