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That said, peptide bonds and certain side chains can still undergo slow chemical degradation over time, accelerated by light, heat, and oxygen exposure

In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

This is also supported by Migliorini et al

3gss: AJ Oakley, J Rossjohn, M Lo Bello, AM Caccuri, G Federici & MW Parker (1997) The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate