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They were randomly assigned to receive a once-daily oral dose of orforglipron (12 mg, 24 mg, 36 mg, or 45 mg) or a placebo for 36 weeks

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Excessive cytoplasmic lipid accumulation in cardiomyocytes leads to cellular lipotoxicity and thereby promotes a series of harmful conditions, such as insulin resistance and oxidative stress (Jia et al., 2016

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