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Large portions and overeating may increase digestive discomfort because food stays in the stomach longer while taking GLP-1 medications

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10.1007/s40618-017-0792-x 89 KimY.YooS.LimB.HongJ

Histamine is an important chemical messenger in the neuro-immuno-endocrine system, released by cells such as basophils and mast cells

In addition to providing long-term weight loss and possibly remission of T2DM, bariatric surgery is not feasible for large populations, has specific indications, and may result in surgical complications as well as other issues like malabsorption and micronutrient deficiencies