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For all statistical tests, a P value of less than 0.05 was used to identify statistically different values

Chandy suggested

Researchers should confirm that: No

Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and microcephaly

Indirect antioxidants and systems level modulators such as PUFAs, folates or folinic acid, and prebiotics or probiotics also show promise

The contrasting responses to combined mTORC1 inhibition and ferroptosis induction in different cellular contexts are likely dictated by complex factors including genetic mutation landscape, the ratio of polyunsaturated to monounsaturated phospholipids, iron availability, the basal activities of the PI3K/mTORC1 pathway, and the overall cellular redox state