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Hoekstra, A

Further optimization of the timing, dose, and duration of IGF-1R mAb treatment is warranted in order to maximize benefits while minimizing risks, particularly given recent evidence that transient administration of other drugs can have persistent benefits on age-related outcomes 43

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These differences mean that impressive mouse results frequently translate to modest human outcomes

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The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging