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Drugs administered by IN penetrate through the nasal epithelial barrier, followed by diffusion into the perivascular or perineural spaces, and finally throughout the brain though some of the drug will be lost by entering the lymphatic and systemic blood circulation [12]

These injections are great for those who have trouble absorbing B12 or get hurt by shots in muscles

Nutr Metab 14(1):78 Kutzbach C, Stokstad ELR (1971) Mammalian methylenetetrahydrofolate reductase Partial purification, properties, and inhibition by S-adenosylmethionine

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B12 is a cofactor for succinyl-CoA synthesis and for the conversion of homocysteine to methionine