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Because in research protocols they are administered simultaneously, in equal doses and at the same injection moment

A 2025 study in Diabetes, Obesity, and Metabolism found that participants reported improvements in food-related thoughts, feelings of fullness, and overall healthier eating behaviors

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As phase II enzymes, GSTs detoxify chemical compounds through catalyzing nucleophilic attack by the thiol group in reduced glutathione (GSH) on a wide range of electrophilic substrates [37, 40, 41]

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Nonetheless, the appearance of brown to black discoloration, even intraorally, can be esthetically displeasing to some patients