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261 On the other hand, SIRT4 suppresses tumor growth by inhibiting glutamine metabolism, 262,263 and upon downregulation, it inhibits apoptosis and desensitizes cancer cells to chemotherapy

Hu X, Wang Y, Gao X, Xu S, Zang L, Xiao Y, Li Z, Hua H, Xu J, Li D

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Together, they form a recycled antioxidant system that works much more efficiently than either individually

"Inborn errors in the metabolism of glutathione"

This is consistent with GHK-Cus known role in upregulating collagen synthesis in dermal fibroblasts, a mechanism confirmed in a comprehensive review in Biomolecules documenting GHK-Cus influence across more than 4,000 human genes involved in tissue remodeling and repair