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JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

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For many metabolomics studies, the ratio is a practical comparative readout, whereas redox potential provides a more explicit thermodynamic description when concentration and pH data are sufficiently reliable

It influences mitochondrial respiration and apoptosis, which are crucial for maintaining energy homeostasis (Litvinova et al., 2015)

Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF