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This function of GLP-1 under an inflammatory condition shows the therapeutic possibility of GLP-1 in the depressive brain accompanied by neuroinflammation
Mattioli 1885 Journals (2022)
60 HuangY.YuanK.TangM.YueJ.BaoL.WuS.et al (2021a)
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Sleep deprivation and chronic stress elevate cortisol levels, which blunt GLP-1 response and disrupt appetite control
Other reported effects included: Transient fatigue Reduced appetite (therapeutically desirable in the context of weight loss) Mild injection-site reactions Altered skin sensations or cutaneous hyperesthesia (reported in ~7% of participants, mild and non-serious) Serious adverse events were rare and occurred at similar rates in the retatrutide and placebo groups (approximately 4%)
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