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However, there have been no large-scale human trials to support their use.

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For instance, foods rich in soluble fiber, such as oats and legumes, can promote a healthy gut environment that may enhance GLP-1 secretion

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Proper handling and storage help minimize degradation processes such as hydrolysis, oxidation, and peptide aggregation, which can affect experimental consistency

Compared with chemically synthesized drugs, natural product-derived therapeutics offer significant advantages, including superior biocompatibility and functional diversity, attributes shaped by evolutionary optimization through long-term natural selection (Yao et al., 2017)