One possibility is that diminishment of NADPH also inhibits thioredoxin reductase in the cytosol, and that cytosolic glutathione becomes more oxidized because it must compensate in the reduction of reactive oxygen species for the shortage of reduced thioredoxin
Some side effects include:
These compounds block the activity of an important enzyme, Tyrosinase which is the main enzyme that produces melanin
For example, STI1, a highly selective small-molecule SQOR inhibitor developed by 2 S catabolism raises endogenous H 2 S levels, thereby activating cardioprotective signaling pathways such as protein sulfhydration
PMID: 1220811 Finkel T, Holbrook NJ
Allergic reactions: Some severe, in patients who were allergic to natt (fermented soybeans)