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"Head-to-head trials are a gold standard for comparing potential treatments," Kenneth Custer, executive vice president and president of Lilly Cardiometabolic Health, said in a news release

They demonstrated that pre-treatment with the GLP-1 receptor antagonist, exendin-(939), significantly reduced the entry of both GLP-1 and exendin-4 into various brain regions

a peptide approved for clinical use) and GLP-1 (purple), respectively

It is studied for its potent effects on weight loss, metabolic regulation, and insulin sensitivity

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