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Because the digestive system breaks down proteins, oral semaglutide needs higher doses to achieve the same effect as injectionstypically 7-14 mg daily compared to 0.5-2.4 mg weekly by injection

[1] Fielding, R., Riede, L., Lugo, J., & Bellamine, A

Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects

10 The investigators proposed that the significant impact on weight loss was secondary to reduced calorie consumption and increased satiety in the metformin cohort, an effect that was dose dependent

They then took them off the medication and stopped the lifestyle interventions

some even opt to continue receiving low doses of tirzepatide or semaglutide near Brentwood, TN, long-term to manage their weight