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J Inherit.Metab Dis 2008;31(4):503-507

PMID: 27456681 Lobo, V

1e): 3,9,14,15,30,34,46,57,60 (i) The thiolate of the reduced monothiol class I glutaredoxin directly attacks the disulfide substrate followed by the stepwise reduction of the mixed disulfide and Grx(SSG) by two molecules of GSH

Emodin also inhibits NLRP3 expression and reduces pro-inflammatory factors like interleukin-1 (IL-1), IL-6 and TNF-

10.1016/j.freeradbiomed.2018.09.043 50 IngoldI.BerndtC.SchmittS.DollS.PoschmannG.BudayK.et al (2018)

Moreover, FOXO4-DRI significantly decreased the viability of senescent Leydig cells and dramatically increased their apoptosis rate from 10% to 27%