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Inability to maintain adequate caloric intake (eating less than 800 calories per day due to appetite suppression and nausea combined)

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One twin was randomly assigned to receive an infusion of oIGF-1 at either 22 g h 1 (n = 1) or 220 g h 1 (n = 2), and the other twin received a volume matched infusion of saline in 0.5% BSA (n = 3)