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These drugs by increasing insulin secretion and possibly, beta cell mass, decrease plasma glucose and lipids and have a secondary action to reduce food intake and bring about weight loss

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Although the frequency of acute pancreatitis is uncommon, healthcare professionals should be aware that pancreatitis has been associated with GLP-1 and GLP-1/GIP receptor agonists, and to stay alert to signs and symptoms in their patients. The spokesperson stresses that Novo Nordisk continues to collect safety data, and that it welcomes any new research that will help it understand GLP-1 treatments

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For AMPK activation or inhibition, according to the aforementioned procedure (Zhang et al., 2009