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The pulse of growth hormone it produces is sharp but brief: a fast spike followed by a fast fall as the peptide is metabolized
The need for large-scale replication of these studies in Western cultures is evident to further validate these associations
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Finally, the biology of non-response and therapeutic resistance - including the role of gut microbiome composition, adipose tissue dysfunction phenotypes, and genetic determinants of drug metabolism - represents a frontier for translational investigation to improve patient outcomes
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