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Hydrophobic peptides or those containing sensitive structures (like disulfide bonds) may require special solvents (e.g., DMSO) or pH adjustments for proper reconstitution

Change in vision (particularly in those with diabetic retinopathy) Hypoglycemia (low blood sugar) dizziness or light-headedness, sweating, shakiness, blurred vision, slurred speech, weakness, anxiety, hunger, headache, irritability or mood changes, confusion or drowsiness, fast heartbeat, or feeling jittery

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However, they can co-occur in the same individual, with studies suggesting 6-14% of autistic people also have dyslexia

This method is suitable for hydrophilic drugs but often yields low encapsulation efficiency due to the large volume of external aqueous phase