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FOXO4-DRI (also known as Proxofim) is a synthetic peptide with a retro-inverso structure, developed by Dutch researchers as a modified version of the FOXO4 protein with an extended half-life
While the peptides activation of ENC-alpha in the lungs is a good thing in pneumonia where fluid literally interferes with breathing, the investigators were concerned that activating ENaC-alpha in the kidneys might disturb normal sodium retention, which is important to the kidneys role in blood pressure regulation
Hug G, et al
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