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Ruenzi et al., 2005) and in experimental rat studies (see Duzel et al., 2017), and has very safe profile (LD1 could be not achieved) (Seiwerth et al., 2018), a point recently confirmed (Xu et al., 2020)

If both are elevated, the inflammatory signal is stronger

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Toxicity of nanoparticles on the reproductive system in animal models: A review