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In thyroid cancer, for instance, GLP-1R is predominantly expressed in parafollicular C cells

Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with (OZEMPIC OR RYBELSUS OR WEGOVY) [see Contraindications (4), Warnings and Precautions (5.1)]. Mounjaro and Zepbound have the following boxed warning (2025) (formerly known as a black box warning), related to Tirzepatide the main ingredient in Mounjaro and Zepbound, set forth below: WARNING: RISK OF THYROID C-CELL TUMORS In both male and female rats, tirzepatide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures