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During dose escalation The first few weeks on any GLP-1 medication are the riskiest for side effects
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For example, in a prospective study aimed at investigating the influence of GLP-1RA and DPP4 inhibitors on the development of depression in patients with newly diagnosed T2DM, participants receiving incretin-based therapies displayed marked reduction of depressive symptoms after one year, when compared to the control group
Forrest JA, Clements JA, Prescott LF
On the other hand, AGEs bind to the RAGE on the RPE cell membrane, disrupting iron metabolic homeostasis and accelerating the ferroptosis process in RPE cells (183185)
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