albicans relies on multiple alternative carbon pathways to survive macrophage phagosomes, enhance stress/antifungal resistance, and drive virulence, showing these pathways act as both nutrient sources and environmental signals (Williams and Lorenz, 2020)
A message is only useful if the cell has the energy to act on it, which is why fueling the system with NAD+ and then directing specific work with a peptide can be a logical pairing
The homogenates were centrifuged at 500 g for 15 min
These are favorable odds for a relatively low-risk intervention, but they underscore that peptide therapy does not work for everyone
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Lyttle MH, Hocker MD, Hui HC, Caldwell CG, Aaron DT, Engqvist-Goldstein A et al