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It is not an automatic no, but it is an individualized decision that should be made with a prescriber who can weigh your history against the benefits and set up appropriate monitoring

MT-1 (Melanotan I) acts as a non-selective melanocortin receptor agonist and stimulates pigmentation primarily through MC1R activation in melanocytes, which regulates melanin synthesis and increases eumelanin production

CLOCK and BMAL1 the positive transcriptional activators in the core circadian loop have been shown to regulate DNA damage response pathways and to interact directly with telomere-binding proteins

Imperato, A., Ramacci, M