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The impact of efflux transporters in the brain on the development of drugs for CNS disorders
Lancet Oncol 11: 155-164
Kishi T, Rider LG, Pak K, Barillas-Arias L, Henrickson M, McCarthy PL, Shaham B, Weiss PF, Horkayne-Szakaly I, Targoff IN, Miller FW, Mammen AL (2017) Association of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autoantibodies with DRB1*07:01 and severe myositis in juvenile myositis patients
The Sonic hedgehog signaling pathway is activated in pancreatic tumor CSCs, and sanguinarine has been shown to play a role in the secondary pathway, while sanguinarine upregulates E-cadherin and inhibits N-cadherin to inhibit the EMT process and prevent pancreatic cancer progression
DHODH, Dihydroorotate Dehydrogenase
GPX5 is an unusual member of the mammalian GPX family because, unlike the well-known mammalian GPX1-4, it does not contain selenosylcysteine (Secys) at its active site, but instead has cysteine residues (Cys) as its active site (Taylor et al., 2013)
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