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Owing to the pleiotropic effects of GSH on cell functions, it has been quite difficult to define the role of GSH in the onset and/or the expression of human diseases, although significant progress is being made

In addition, it highlights a set of mechanistically coherent therapeutic entry pointssuch as M1-targeted delivery, mitochondrial protection, ROS scavenging, and immunometabolic reprogramming (M1M2)which form the basis for nanoparticle-based interventions discussed in subsequent Sect [50]

Advanced Cylosome Delivery System

Liposome Res

[7] High-dose methionine may antagonize the therapeutic effect of L-dopa-carbidopa regimens by increasing peripheral methylation of the drug complex, potentially reducing central bioavailability

As the HPT axis has long been involved in the research of depression (106), it is reasonable to believe that the dysfunction of the HPT axis in GD, with its effect of disrupting neurotransmitter metabolism, inducing oxidative stress, contributing to other complications and so forth, has a potentially vital effect on the development of depression