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Then 5 L of mixture containing BCPB and TCEP was added

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

Radtke MD, Pitts SJ, Jahns L, Firnhaber G, Loofbourrow BM, Zeng A, et al

SSRP Institute News (2026) 11

The decrease of glutathione levels has been detected in several AD mouse models including triple-transgenic (3X-AD-Tg) and APP/PS1 mouse 61,62

In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]