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To simulate different clamp conformations, we kept both BRCT domains to account for structural constraints

This bidirectional interaction enables restoration of normal NO balance critical for proper sphincter timing

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Synthesis and evaluation of n-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors

Under normal conditions, this pathway permits controlled passage of water and small ions while restricting larger solutes and luminal macromolecules