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Research notes greater activity in circumstances where sleep is already disturbed, with minimal effects in healthy subjects without sleep complaints

X-ray crystallography and NMR spectroscopy have established that copper coordinates through a 3N1O equatorial square-planar pyramid configuration: the histidine imidazole nitrogen, the glycine -amino nitrogen, and the deprotonated amide nitrogen of the glycine-histidine peptide bond, with additional oxygen coordination from neighboring complex carboxyl groups