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J Immunol (2021) 206(8):184457

doi: 10.1016/S2213-8587(15)00482-9 46 GasbjergLSBergmannNCStensenSChristensenMBRosenkildeMMHolstJJet al

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Patients should be counseled to: Consume smaller, more frequent meals (56 per day) rather than large portions Emphasize low-fat, low-fiber foods that empty more readily from the stomach Ensure adequate hydration, particularly with liquid calories if solid food tolerance is poor Avoid lying down immediately after meals Chew food thoroughly and eat slowly For patients developing concerning symptoms, temporary dose reduction or treatment interruption may be necessary

Clinical trials of these antibiotics account for normal variation in absorption rates

The peak heart rate effect is temporary, not permanent