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First, it derives from a larger gastric protection protein
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Transport of urate via SLC22A12 is selectively inhibited by lactate, succinate, -hydroxybutyrate, and acetoacetate
Adding GIP (the tirzepatide model) deepens the effect and, somewhat counterintuitively, appears to improve gastrointestinal tolerability relative to GLP-1 alone
A licensed compounding pharmacy can legally produce a formulation that has not been studied for efficacy, as long as a licensed prescriber writes the prescription
Dosing remains standard: 5001,000 mg every 46 hours, not exceeding 3,0004,000 mg daily
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