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24 In this review, we discuss the benefits and challenges associated with the small-molecule GLP-1 RA drugs from pre-clinical and clinical studies

This combination contributes to improved glucose control and weight loss

Sustainability after stopping the medication depends heavily on the behavioral and lifestyle changes established during treatment

These include gastrointestinal effects like nausea, vomiting and abdominal pain, as well as fainting, headache, migraine, dehydration, acute pancreatitis and gallstones

Adverse reactions are possible and may pose a risk to patients

There is one new side effect, however, that was not seen in earlier Phase 2 trials