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Sleire L, Skeie BS, Netland IA, Frde HE, Dodoo E, Selheim F, et al

In such severe cases, cerebral oedema becomes clinically apparent 12 hours to 4 days after the overdose [18, 20, 50, 87], although CNS depression may be delayed if a slow-release preparation has been ingested [12, 50]

doi: 10.1053/j.gastro.2017.05.056

The expanded Enterobacteriaceae release LPS, activating the TLR4/MyD88 axis to upregulate epithelial NOX1 expression, thereby driving secondary ROS bursts that amplify epithelial barrier disruption and inflammatory cascades [404]

Meanwhile, androgens (male hormones) remain active