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PIONEER 3 PIONEER 3 compared the efficacy and safety of the addition of oral semaglutide or the DPP-4 inhibitor sitagliptin as add-on therapy in patients with T2DM receiving metformin with or without a sulfonylurea

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The results demonstrated that the 25mg daily pill delivered clinically meaningful weight loss: Average weight loss of 13.6-16.6% compared to 2.2-2.7% with placebo 76% of participants achieved at least 5% weight loss versus 31% on placebo Over 30% achieved 20% or greater weight loss Significant improvements in blood pressure, cholesterol, and inflammatory markers These results are comparable to what weve seen with injectable Wegovy, which typically produces 12-15% weight loss

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