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In EVOKE and EVOKE+, oral semaglutide lowered several cerebrospinal-fluid markers of Alzheimers pathology, including phosphorylated tau and total tau, by up to roughly 10%, yet produced no measurable slowing of clinical decline

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10.1016/j.bj.2025.100849 Biomed

Basu and Kulkarni, 2019

However, more human studies are needed to assert that choline supplementation during pregnancy improves cognitive performance in the offspring or that choline supplementation helps prevent cognitive decline in older people

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