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Abbreviations AMPK: AMP-activated protein kinase CNS: Central nervous system DIO: Diet-induced obesity FGF21: Fibroblast growth factor 21 GCGR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide 1 K ATP channel: ATP-sensitive potassium channel MBH: Mediobasal hypothalamus NAFLD: Non-alcoholic fatty liver disease PKA: Protein kinase A STZ: Streptozotocin References Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA (1922) Pancreatic extracts in the treatment of diabetes mellitus

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By inhibiting GPX4 and GSS, solasonine increased the amounts of lipid ROS in HepG2 cells to produce these effects (132)