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Overexpression of GSTs may contribute to increase detoxification of anticancer drugs 68
GS-conjugates are actively transported out of cells by efflux transporters including MRP1 and P-glycoprotein belonging to the superfamily of ATP-binding cassette transporters 70,71,72
Rate-Controlled Administration IV push is possible for glutathione, but slower infusion allows better cellular uptake and reduces the risk of sulfur-related reactions (temporary garlic odor in breath harmless but manageable with slow administration)
4 (download XLSX Source data for Fig
doi:10.1073/pnas.94.23.12627
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