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Theyre eating well, exercising regularly, and doing everything right, yet their weight still creeps upward, energy dips, and metabolism seems to stall

Peer review Peer review information Nature Metabolism thanks the anonymous reviewers for their contribution to the peer review of this work

Collectively they belong to a class of glucagon-like peptide 1 (GLP-1) analogs that has reshaped the treatment of obesity and diabetes so thoroughly that the word blockbuster barely covers it

Depending on the patient and their prior surgery, this can include conversion to a duodenal switch (SADI-S or BPD/DS) or Roux-en-Y gastric bypass

Clinical trials demonstrate that patients who remain at lower doses experience more modest benefits compared to those who reach higher maintenance doses