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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface

Comparing Supplement Formats When looking for a glutathione supplement, you will likely encounter several different formats

Pycnogenol is a nutritional supplement derived from French maritime pine bark extract

Contains glutathione precursors to support natural antioxidant production

A dermatologist-formulated glutathione supplement with liposomal absorption to support even skin tone, reduce pigmentation, and reveal a brighter, radiant glow