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ROS are involved in many physiological functions of the ovary such as steroidogenesis, oocyte maturation, ovulation, formation of blastocysts, implantation, luteolysis and maintenance of the luteal phase (124, 125)

however, no differences were observed in T3, T4, or TSH levels.31 An increased risk of osteopeniaup to fourfold higherhas been reported in patients with PG vs individuals without gray hair.32 Nevertheless, more recent studies failed to confirm this association.33 In cases of PG, a laboratory work-up may be necessary, including iron studies, vitamin B12, folic acid, 25-hydroxyvitamin D, thyroid profile, and antithyroid antibodies.3133 Clinical features Gray hair primarily results from an optical phenomenon

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In an animal model of obstructive sleep apnea, treatment with vitamins C and E was associated with reduction in markers of both oxidative and carbonyl stress resulting from intermittent hypoxia