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Clinical ASD arises from diverse etiologies including de novo mutations (e.g., SHANK3, CHD8), copy number variations, and polygenic risk factors [44]
Some patients may notice changes sooner than others, while some may require ongoing provider evaluation to determine whether treatment should continue
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use plain sterile water for immediate single-use applications Bulk Purchasing: Order 25-packs or cases for facilities with routine bacteriostatic water requirements to reduce per-unit cost Preservative Sensitivity: Confirm the patient has no benzyl alcohol allergy before using medications reconstituted with bacteriostatic water Route of Administration: Verify the drug's approved administration routes
doi: 10.1016/S0021-9258(18)42531-8 84 ChenYEDruckerDJ
Desde una perspectiva evolucionista, este fenmeno se explica porque en los tiempos de los cazadores-recolectores se seleccionaron aquellos seres humanos con el fenotipo ms eficiente en cuanto a ahorro y almacenamiento de energa
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