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Roles of GLP-1RAs signaling in autoimmune and autoinflammatory diseases Psoriasis Psoriasis is a persistent, non-contagious, incurable inflammatory condition that is distinguished by erythematous plaques covered with silvery-white scales on the skin [190, 191]

In the SURMOUNT clinical trial program, tirzepatide demonstrated superior weight reduction compared to semaglutide alone, with average losses ranging from 16% to 22% depending on dose progression

While pancreatitis risk at microdose levels is theoretical rather than documented, monitoring lipase levels at baseline and periodically is prudent, especially in patients with any history of pancreatic issues

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However, this approach can also lead to unpredictable side effect patterns and inconsistent medication efficacy

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