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No, splitting semaglutide doses is not recommended and is not supported by clinical evidence

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Downside #2: Management and Expenses The injectable form of semaglutide requires a weekly injection, which can prove bothersome for some people [12]

In patients with severe early-onset obesity, most of the common mutations are clustered in the leptin-melanocortin pathway (LMP), which mainly regulates appetite to control the bodys energy balance