Important note
Pharmacological management includes: Levodopa/carbidopa : The gold standard treatment that replenishes brain dopamine Dopamine agonists : Medications like pramipexole and ropinirole that directly stimulate dopamine receptors MAO-B inhibitors : Rasagiline, selegiline, and safinamide, which prevent dopamine breakdown COMT inhibitors : Entacapone and opicapone, which prolong levodopa action Amantadine : Used for dyskinesia management and mild symptom control Anticholinergics : Occasionally used for tremor in younger patients Non-pharmacological interventions are equally important and include physical therapy, occupational therapy, speech therapy, and regular exercise
Stacking tesofensine with GHRH analogs allows fat oxidation (via increased lipolysis from elevated GH) without compounding CNS stimulation
Fatouros IG, Douroudos I, Panagoutsos S, Pasadakis P, Nikolaidis MG, Chatzinikolaou A, Sovatzidis A, Michailidis Y, Jamurtas AZ, Mandalidis DJM, et al
72 Studies have shown MCT-enriched diets, with 910% of daily calories as MCTs for three months, may augment conventional therapies in dogs with epilepsy by improving spatial-working memory, problem-solving ability, and owner-reported trainability 73
Science 334 , 809813 (2011)