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Discussion Intact brain Our analytical approach using high-resolution in vitro NMR spectroscopy study confirmed that glutamate, which acts as an excitatory neurotransmitter and important metabolic and nitrogen metabolite, is highly concentrated in all intact brain regions

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That is the test that matters, and sublingual does not pass it reliably

doi: 10.1016/j.heliyon.2022.e09725 564 BodkeHJogdandS

PBN was also shown to interfere with genes encoding inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines (Maples et al., 2004

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